Search on: POLYPYRIMIDINE TRACT BINDING PROTEIN 
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Descriptor English:   Polypyrimidine Tract-Binding Protein 
Descriptor Spanish:   Proteína de Unión al Tracto de Polipirimidina 
Descriptor Portuguese:   Proteína de Ligação a Regiões Ricas em Polipirimidinas 
Synonyms English:   PTB Protein
PTB Splicing Factor
p57 Cytoplasmic RNA-Binding Protein
pPTB
Polypyrimidine Tract Binding Protein
Splicing Factor, PTB
Tract-Binding Protein, Polypyrimidine
p57 Cytoplasmic RNA Binding Protein  
Tree Number:   D12.776.157.725.829.250
D12.776.664.962.829.250
Definition English:   A RNA-binding protein that binds to polypyriminidine rich regions in the INTRONS of messenger RNAs. Polypyrimidine tract-binding protein may be involved in regulating the ALTERNATIVE SPLICING of mRNAs since its presence on an intronic RNA region that is upstream of an EXON inhibits the splicing of the exon into the final mRNA product. 
History Note English:   2003; use POLYPYRIMIDINE TRACT-BINDING PROTEIN (NM) 1991-2002 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   37409 
Unique Identifier:   D038941 

Occurrence in VHL:
 

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